在接受非典型抗精神病药物治疗的精神分裂症患者中的严重程度
Syed Meraj Alam Fatmi J1, Rakesh Koul1, Prakash Suruchi1
1Department of Pharmacology, KD Medical College, Hospital & Research Center, Mathura, India.
Bioinformation
|September 13, 2023
概括
对精神分裂症的非典型抗精神病药物通常会引起可能的不良药物反应 (ADR),大多是轻微的. 性别和疾病持续时间等风险因素显著影响患者的副作用严重程度.
科学领域:
- 精神病学是一个精神病学.
- 药物监督 药物监督 药物监督
- 临床药理学 临床药理学
背景情况:
- 非典型抗精神病药物是精神分裂症的首要治疗方法,提供较少的额外金字塔症状 (EPS),但具有不同的药物不良反应 (ADR) 概况.
- 了解ADR的概率,发生和风险因素对于优化患者管理至关重要.
研究的目的:
- 为了前性地分析与非典型抗精神病药物治疗的精神分裂症患者的药物不良反应 (ADR) 相关的概率,发生率和重大风险因素.
- 用格拉斯哥抗精神病药物副作用量表 (GASS) 评估副作用的严重程度.
主要方法:
- 一项前性观察性研究涉及140名精神分裂症患者,这些患者被处方了非典型的抗精神病药物.
- 纳兰乔因果关系评估尺度用于ADR概率和GASS用于严重程度.
- 使用SPSS v25.25进行描述性统计和千平方分析.
主要成果:
- 大多数副作用被评为"可能" (55%),大多数副作用是"轻微" (55.71%).
- 在性别和副作用严重程度之间,以及疾病持续时间和副作用严重程度之间 (P>0.5) 发现了显著的关联.
- 在39.29%的患者中报告了COVID-19感染.
结论:
- 这项研究强调了在接受非典型抗精神病药物治疗的精神分裂症患者中常见的可能和轻微的副作用.
- 确定了重要的风险因素 (性别,疾病持续时间) 可以为改进的管理策略提供信息.
- 这些发现有助于更安全的临床方法和加强精神病患者的治疗指南.
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