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Updated: Jul 16, 2025

An Ex Vivo Laser-induced Spinal Cord Injury Model to Assess Mechanisms of Axonal Degeneration in Real-time
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活跃收缩保护神经元在轴突切割后的神经元

Mehmet Şerif Aydın1, Sadık Bay1, Esra Nur Yiğit1

  • 1Regenerative and Restorative Medicine Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul 34810, Türkiye.

iScience
|September 13, 2023
PubMed
概括

神经元在受伤后缩小,以防止胀和细胞死亡. 这种新发现的保护机制涉及到actomyosin收缩和calpain活动,这对于生存轴突损伤至关重要.

关键词:
生物科学 生物科学神经科学是一个神经科学.生理学 生理学 生理学

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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