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移植后胆道并发症使用70岁以上已故捐赠者的肝移植:回顾性病例对照研究

Carlos Jimenez-Romero¹, Iago Justo-Alonso¹, Pilar Del Pozo-Elso¹

¹Unit of HPB Surgery and Abdominal Organs Transplantation, `12 de Octubre´ University Hospital, Madrid 28041, Spain.

World journal of gastrointestinal surgery

|September 13, 2023

概括

使用老年捐赠者 (>70岁) 移植的肝脏移植显示,胆道并发症 (BC) 的发生率很低. 大多数BC病例得到了成功的治疗,对患者或移植的存活率没有显著影响.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器

背景情况:

由于肝移植的短缺,需要扩大捐赠者池,包括老年捐赠者.
较老的捐赠人肝移植 (年龄>70岁) 在移植方面存在独特的挑战.

研究的目的:

为了研究肝移植 (LT) 后胆道并发症 (BC) 的发生率,结果和危险因素,使用来自70岁以上捐赠者的移植.
评估使用老年捐赠肝脏在LT的安全性和有效性.

主要方法:

250例肝移植的回顾性病例控制研究,使用年龄大于70岁的捐赠者.
对那些在LT后发展BC的患者 (n=21) 与没有BC的患者 (n=229) 的比较.

主要成果:

结核病的发病率为8.4%,包括静脉狭窄和胆道泄漏.
女性捐赠者是保护性的,而捐赠者心脏骤停是BC的危险因素.
患者和移植的生存率在各组之间相似,BC很少致命.

结论:

来自>70岁的捐赠者的肝移植可以使用,BC的发病率相对较低.
穿皮扩张和Roux-en-Y肝脏支结管切除术是BC的有效管理策略.
使用较老的捐赠者移植并不会显著地影响患者或移植物的长期存活.

关键词:

胆道并发症胆道并发症胆道狭窄是因为胆道狭窄.肝脏移植是什么?肝移植是什么?八代性捐赠者的捐赠者较老的肝脏较老的肝脏七十多岁的捐赠者

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