危险因素及其对严重急性胰腺炎的相互作用影响,并与急性胃肠道损伤复杂
Jian-Hui Chen1, Mei-Fen Zhang1, Wen-Chao Du1
1Emergency Department, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China.
World journal of gastrointestinal surgery
|September 13, 2023
概括
高APACHE II分数和较高的肌素水平是严重的急性胰腺炎与胃肠道损伤的关键风险因素. 这些因素具有积极的相互作用,增加了严重急性胰腺炎患者的风险.
科学领域:
- 胃肠病学 胃肠病学
- 临界护理医学 临界护理医学
- 临床研究 临床研究
背景情况:
- 严重的急性胰腺炎 (SAP) 可以导致急性胃肠道损伤 (AGI).
- SAP与AGI的风险因素已知,但它们的相互作用研究不足.
- 了解这些相互作用对于患者管理至关重要.
研究的目的:
- 识别SAP的风险因素与AGI复杂.
- 分析这些已识别的风险因素的相互作用影响.
- 通过AGI.提供对SAP病理生理学的见解.
主要方法:
- 168名SAP患者的回顾性分析 (2019年12月 - 2022年6月).
- 患者分为AGI和非AGI组.
- 在人口和实验室数据上进行的多因素后勤回归和相互作用分析.
主要成果:
- AGI组的多器官功能障碍综合征,APACHE II评分,白细胞计数和肌素 (CRE) 水平的比率更高.
- APACHE II评分> 15和CRE> 100μmol/L被确定为具有AGI的SAP的独立风险因素 (P <0.05).
- 在APACHE II分数和CRE水平之间观察到一个积极的相互作用 (指数 = 3.123).
结论:
- 较高的APACHE II评分 (> 15) 和CRE水平 (> 100μmol/L) 是SAP与AGI复杂的重要独立风险因素.
- 在预测SAP患者的AGI时,高APACHE II分数和高CRE水平之间存在协同,积极的相互作用.
- 这些发现强调了监测这些标志物对于SAP的早期干预的重要性.
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