对阿米奥达龙诱导的视网膜和视神经毒性的新见解:功能和结构变化
Weam Mohamed Ebeid1,2, Amany Abd El-Fattah El-Shazly1, Norhan Mohamed Kamal1
1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Therapeutic advances in ophthalmology
|September 13, 2023
概括
在没有视觉症状的患者中,慢性使用阿米奥达龙并没有显示出显著的视网膜或视神经变化. 先进的成像和电生理学测试显示,与健康对照人群相比,没有功能或结构上的差异.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
背景情况:
- 阿米奥达龙是一种常见的抗心律不整的药物,用于心律不整.
- 以前的研究表明,慢性使用阿米奥达龙和视神经病变之间存在潜在的联系.
- 目前的研究调查了阿米奥达龙的亚临床眼睛效应.
研究的目的:
- 检测视网膜和视神经中微妙的结构或功能变化.
- 为了评估长期接受阿米奥达龙治疗且没有视力投诉的患者.
- 为了比较阿米奥达龙使用者的眼睛发现与健康的对照组.
主要方法:
- 一项观察性研究涉及15名慢性阿米奥达龙治疗患者和15名健康对照患者.
- 电生理学测试包括模式视觉唤起潜能 (PVEP),模式电网红图 (PERG) 和多焦点电网红图 (mfERG).
- 进行光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCTA),以评估视网膜和视神经结构.
主要成果:
- 在阿米奥达龙和对照组之间没有发现PVEP,PERG或mFERG的显著差异.
- OCT和OCTA在斑点或视神经头部没有显著的结构或功能变化.
- 在光盘形态,特别是杯/盘比和边缘面积方面,发现了微小的统计学意义上的差异.
结论:
- 慢性阿米奥达龙治疗,在没有视觉症状的情况下,没有导致视网膜或视神经的明显结构或功能变化.
- 电生理学测试和高级成像 (OCT,OCTA) 没有显示出明显的眼睛毒性.
- 微妙的光盘变化需要进一步调查,但并不表明明显的视力障碍.
关键词:
艾米奥达龙是一种阿米奥达龙.电网红学 (electroretinography) 是一种电网红学 (electroretinography) 的方法,可以通过电网红学 (electroretinography) 进行测试.多焦点电网膜学 (multifocal electroretinography) 是一种多焦点的电网膜学.视神经病变是一种视神经病变.光学连贯性断层扫描血管图谱视觉唤起的潜在潜力更多相关视频
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