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在帕金森病中,最佳的亚thalamic刺激部位和相关网络用于结步态

Houyou Fan^1,2, Zijian Guo^1,3, Yin Jiang^2,4

¹Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, China.

Brain communications

|September 13, 2023

概括

这项研究确定了下体内核内的最佳深度大脑刺激 (DBS) 部位,用于治疗帕金森病. 它还揭示了影响DBS症状改善或恶化的特定大脑网络.

科学领域:

神经科学是一个神经科学.
神经外科神经外科
神经学神经学

背景情况:

步态结 (FOG) 是帕金森病 (PD) 的残疾症状之一.
高频体下深脑刺激 (STN-DBS) 是一种PD治疗方法,但其对FOG的影响有所不同.
对于FOG在PD中的最佳刺激目标和网络仍然不清楚.

研究的目的:

为了确定在FOG.PD患者中STN-DBS的亚thalamic核内的最佳刺激部位.
探索结构和功能大脑连接网络,预测STN-DBS后的FOG变化.
为了在FOG的PD患者队列中验证这些发现.

主要方法:

76名患有FOG的PD患者接受双边STN-DBS的回顾性分析.
估计激活组织体积和绘制最佳/酸刺激部位的地图.
从帕金森病进展标记者倡议数据库中识别使用规范连接组的预测连接网络.

主要成果:

最佳的刺激部位是体内亚体核的三分之二.
特定的纤维通道连接到调节FOG的运动和前额区域.
缓解FOG与SMA,SMA前和PNP通道调节相关;与中介/腹侧前额皮层通道相关的恶化.

结论:

确定并验证了PD中FOG的最佳STN-DBS站点和预测连接网络.
了解这些网络可以指导个性化的STN-DBS治疗策略.
未来使用定向线索可能会增强PD-FOG的个性化DBS治疗.

关键词:

帕金森病是帕金森氏症的一种疾病.连接网络连接网络的连接.结了人的步态.最佳的模拟场所是最佳的模拟场所.亚thalamic深度大脑刺激的刺激.

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