化多个纳米颗粒与Hydroxyapatite涂层显示在体内各种健康影响
Xinlin Li1,2, Baojuan Yang3,4, Mengfei Xu1,2
1Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People's Republic of China.
International journal of nanomedicine
|September 13, 2023
概括
这项研究开发了一种用于植入物的新型酸涂层 (HASiGdCe),增强了抗菌,血管和骨质的特性. 新的涂层显示了改善骨愈合和预防骨科和牙科应用中的感染的前景.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 纳米技术 纳米技术
背景情况:
- 植入物上的酸 (HA) 涂层缺乏骨诱导性,血管生成性和抗菌性.
- 这限制了它们在骨科和牙科应用中的有效性.
研究的目的:
- 开发一种具有增强抗菌,血管新生和骨质新生特性的新型HASiGdCe涂层.
- 为了评估这种涂层用于骨科和牙科植入物的性能.
主要方法:
- 用等离子喷雾技术制造HASiGdCe涂层.
- 包括SEM,XRD,FTIR和机械测试在内的全面表征.
- 在体外评估抗菌,细胞相容性,骨质生和血管生活性.
- 在体内评估,使用受感染动物的股骨模型.
主要成果:
- 该HASiGdCe涂层表现出适当的形态,相位,粘合强度和生物活性.
- 由于Gd3+和Ce4+释放,对MRSA和PAO-1具有强烈的抗菌活性.
- 与HA涂层相比,在体外具有优越的骨质原和血管原性质.
- 在体内生物安全性,抗微生物和骨质生成性质优异.
结论:
- HASiGdCe涂层显著增强了植入物骨整合,并防止了感染.
- 这种新型涂层在骨科和牙科领域的骨缺陷治疗中显示出有前途的应用.
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