导管相关的脑脊液感染和全身免疫炎症指数之间的关系
Sebnem Nergiz1, Pinar Aydin Ozturk2
1Department of Dietetics and Nutrition, Dicle University, Ataturk Faculty of Health Sciences, Diyarbakir, Turkey.
PeerJ
|September 13, 2023
概括
系统性免疫炎症指数 (SII) 在患有腹腔皮质 (V-P) 偏流感染的儿科患者中升高,特别是那些由非凝结酶负性葡萄球菌引起的. 这一发现可能有助于早期检测感染.
科学领域:
- 儿童传染病 儿童传染病
- 感染中的生物标志物
- 神经临界护理是指神经临界护理.
背景情况:
- 与导管相关的感染,特别是腹腔关节 (V-P) 偏路感染,在儿科患者中具有重大风险.
- 早期诊断和治疗对于减少与这些感染相关的发病率和死亡率至关重要.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与儿科患者的导管相关感染之间的关联.
- 探索SII对预后的影响,并确定VP分路感染的潜在预测因素.
主要方法:
- 在2017年1月至2019年10月期间,对56名患有VP分流感染的儿科患者进行了回顾性分析.
- 临床发现,脑脊液 (CSF) 参数 (蛋白质,葡萄糖,,白细胞) 和血液学/生化标志物的分析.
- 不同致病原体之间的SII水平的比较,包括凝结酶阴性葡萄球菌.
主要成果:
- 系统性免疫炎症指数 (SII) 显著增加在V-P分路感染的患者 (p=0.002).
- 观察到骨髓/血糖比明显较低 (p=0.046).
- 在非由凝血酶阴性葡萄球菌引起的感染中,特别注意到SII升高.
结论:
- 系统性免疫炎症指数 (SII) 可能作为一种有价值的生物标志物,用于检测儿科患者的VP分流感染.
- 需要进一步的研究来探索SII和其他因素在指导实证抗生素治疗中的预测价值.
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