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膝关节骨关节炎患者的结构性和功能性大脑变化:一个范围审查

Joaquín Salazar-Méndez¹, Iván Cuyul-Vásquez^2,3, Nelson Viscay-Sanhueza⁴

¹Laboratorio de Investigación Somatosensorial y Motora, Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Talca, Chile.

|September 13, 2023

概括

膝关节关节炎 (OA) 导致大脑变化,包括改变灰质体积和与疼痛相关的区域的连接性. 大脑基质中的这些神经质变化导致OA患者的慢性疼痛和残疾.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
整形外科整形外科整形外科

背景情况:

膝关节骨关节炎 (OA) 是一种广泛的疾病,导致疼痛和残疾.
除了关节变化之外,OA还会在控制疼痛感知的大脑区域中诱导神经可塑性变化.

研究的目的:

识别和比较膝关节OA患者与健康受试者的结构性和功能性大脑变化.

主要方法:

在多个数据库 (MEDLINE,EMBASE,WOS,CINAHL,SCOPUS,Health Source,Epistemonikos) 进行系统的文献搜索.
提取有关研究和参与者特征的数据,以及大脑评估技术.
使用纽卡斯尔-太华尺度评估的方法质量.

主要成果:

在膝盖骨关节炎患者的胰岛,额头叶,环状皮质,海马体,视觉皮质,叶,前额皮质和基本质中观察到灰色质量的减少.
额叶,核,杏仁体和体感皮质中发现的灰质体积增加.
大脑连接模式发生变化,包括胰岛与前额叶连接性下降,胰岛与前额叶皮层连接性增加.

结论:

观察到的大脑变化表明在膝关节OA的疼痛矩阵内存在显著的神经塑性修饰.
这些神经可塑性变化与膝关节OA相关的慢性疼痛经历有关.

关键词:

脑部成像脑部成像慢性疼痛是一种慢性疼痛.这是一个EEGEEGEEGEEGEEGEEGEEG.科亚科亚是什么意思膝关节骨关节炎是一种关节炎.这就是为什么MRI是MRI.神经可塑性是一种神经可塑性.骨关节炎是一种骨关节炎.

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