相关实验视频

Updated: Jul 16, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

外体在口腔状细胞癌中的新兴功能和应用

Yingchun Qie¹, Xia Sun², Yongqiang Yang²

¹Stomatology Department, Zibo First Hospital, Zibo, Shandong Province, China.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|September 13, 2023

概括

外体,微小的囊泡,在理解和治疗口腔状细胞癌方面表现有前途. 进一步研究它们在瘤生长和转移中的作用可能会为这种常见的口腔癌带来新的治疗策略.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
生物化学生物化学

背景情况:

口腔状细胞癌 (OSCC) 是最常见的口腔癌,尽管目前的治疗方法,但其复发率很高,预后不佳.
现有的手术,化疗和放射治疗等疗法有效性有限,需要新的治疗策略.
外体,细胞外囊泡,越来越多地被认为是它们在细胞间通信中的作用,以及它们对癌症发展的影响.

研究的目的:

对口腔状细胞癌 (OSCC) 中外体的作用进行现有研究进行审查和总结.
探索外体细胞和外体细胞衍生材料在OSCC治疗中的生物功能和潜在应用.
更新对外体参与OSCC瘤发生,进展和转移的理解.

主要方法:

对口腔状细胞癌中外体的前沿研究的文献综述.
对瘤生长,血管新生,侵袭和转移的外体介导影响的分析.
研究外体与瘤微环境的相互作用及其诊断/治疗潜力.

主要成果:

外体在调节口腔状细胞癌的瘤发生,进展和转移方面发挥着重要作用.
外体细胞可以与瘤微环境相互作用,为诊断和治疗提供潜力.
外体衍生材料在开发针对OSCC的新治疗策略方面表现有前途.

结论:

外体是口腔状细胞癌的发展和进展的关键媒介.
了解外体生物学为OSCC的诊断和治疗干预提供了新的途径.
对外体基策略的进一步研究可以显著改善口腔状细胞癌患者的治疗结果.

关键词:

外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.口腔癌是指口腔癌的发生.口腔状细胞癌的癌症.瘤发生的起源

更多相关视频

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

相关概念视频

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...