心血管反射在健康中年人的低强度动态腿部运动中对交感抑制的贡献
Catherine F Notarius1,2, Mark B Badrov1, Tomoyuki Tobushi1
1University Health Network and Sinai Health Division of Cardiology, Toronto General Research Institute, Toronto, Ontario, Canada.
Physiological reports
|September 13, 2023
概括
衰老会增加静止肌肉交感神经活动 (MSNA). 在中年成年人中,心肺巴罗反射和动脉化学反射驱动运动诱导的同情抑制,与年轻人不同.
科学领域:
- 生理学 生理学 生理学
- 运动生理学 运动生理学
- 自主神经系统调节自主神经系统调节
背景情况:
- 衰老与静止肌肉交感神经活动 (MSNA) 的增加有关.
- 了解在运动期间调节MSNA的反射是至关重要的,特别是在老年人群中.
- 之前在年轻人身上进行的研究表明,在动态运动期间,反射的复杂相互作用.
研究的目的:
- 在健康的中年成年人中,研究负责运动诱导的同情抑制的特定反射.
- 将轻度动态腿部运动中的反射反应与年轻人群中的反射反应进行比较.
- 阐明心肺巴罗反射,肌肉代谢反射和动脉化学反射在运动期间调节MSNA中的作用.
主要方法:
- 19名健康的中年成人 (平均年龄56岁) 接受了氧气吸收峰值 (VO2峰值) 的评估.
- 肌肉交感神经活动 (MSNA) 通过微神经图在休息状态和在动态单腿骑自行车时以不同的强度进行测量.
- 使用特定的机动来隔离反射反应:运动后的循环阻塞 (PECO) 用于代谢反射,卧卧姿势用于心肺巴罗反射,以及高氧气对于动脉化学反射.
主要成果:
- 休息的MSNA在仰卧姿势下降,并因高氧化减弱.
- 在轻度动态腿部运动期间,MSNA显著下降,特别是在卧卧的位置.
- 与年轻人不同,肌肉代谢反射在这个中年人群中没有抵消运动期间的同情抑制反应.
结论:
- 在健康的中年成年人中,心肺巴罗反射和动脉化学反射是静止MSNA的关键调节器.
- 中年人的动态腿部运动会导致增强的同情抑制,由这些反射驱动,而不是在年轻人身上看到的反调节性代谢反射.
- 这些发现凸显了运动期间自主神经控制的年龄相关差异.
关键词:
衰老的衰老 衰老的衰老动脉化学反射是一种动脉化学反射.这是心肺肺部的巴罗反射.动态运动是动态的运动.微神经扫描 (microneurography) 是一种微神经扫描.肌肉的代谢反射是肌肉的反射.更多相关视频
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