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在早产相关的阻塞性肺病中,通过振荡计确定了外周呼吸道功能障碍
Michael Cousins1,2, Kylie Hart1,2, Bence L Radics3
1Department of Child Health, Cardiff University School of Medicine, Cardiff, UK.
Pediatric pulmonology
|September 13, 2023
概括
患有阻塞性肺病的早产儿表现出严重的肺功能障碍. 振荡计可以帮助识别这些儿童,并指导支气管扩展剂后的治疗.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统生理学 呼吸系统生理学
- 新生儿医学 新生儿医学
背景情况:
- 肺功能障碍是早产儿的常见并发症.
- 与早产相关的肺病的机制需要进一步阐明.
- 了解肺部表型对于有针对性的干预至关重要.
研究的目的:
- 在早产儿有或没有肺功能障碍时使用振荡计检查肺功能.
- 为了比较不同类型的早产相关肺病和对照之间的肺功能参数.
- 评估运动和支气管扩展剂对肺功能的影响.
主要方法:
- 评估了179名年龄在7-12岁的儿童,15名患有早产相关阻塞性肺病 (POLD),11名患有早产相关维护系数的精神测量损伤 (pPRISm),93名早产对照组和60名早产对照组.
- 利用振荡计来测量阻抗,阻力,反应力和在基线,运动后和支气管扩张后的遵守.
- 根据螺旋测量标准 (FEV1/FVC比率和正常的下限) 分类的早产儿.
主要成果:
- 与两组对照组相比,患有POLD的儿童表现出明显的阻力损伤,抵抗力增加和服从性降低.
- 与术语对照组相比,pPRISm组显示出受损的反应能力和合规性.
- 运动后支气管扩展剂的使用在POLD组中带来了最大的改善,特别是抵抗力和反应能力下降.
结论:
- 患有阻塞性呼吸道疾病的早产儿表现出最显著的振荡度损伤.
- 振荡计是识别早产儿肺部疾病的一个有价值的工具.
- 这些发现支持使用振荡计来早期检测和在受影响儿童中启动治疗.
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