半孔纳米辅助剂的骨架结构对癌症免疫疗法的影响
Jia Tan1,2, Binbin Ding1,2, Hao Chen1,2
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Small (Weinheim an der Bergstrasse, Germany)
|September 13, 2023
概括
半孔二氧化纳米粒子 (MSNs) 显示出免疫治疗的前景. 与其他MSN相比,四素结合MSN (TMSN) 显示出更高的抗原负载,免疫激活和治疗效率.
科学领域:
- 纳米技术纳米技术
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 半孔纳米颗粒 (MSN) 是疫苗和瘤免疫疗法的有前途的纳米辅助剂,因为它们的生物相容性和可调节性质.
- 然而,MSN结构和免疫效应之间的关系尚不清楚,这限制了它们的临床应用.
- 了解这些结构功能关系对于优化基于MSN的免疫疗法至关重要.
研究的目的:
- 综合比较三个具有不同化学结构的MSN:四素键MSN (TMSN),乙氧框架MSN (EMSN) 和纯MSN (MSN).
- 研究化学构造对MSN免疫效应的影响.
- 确定最佳的MSN结构,以增强瘤免疫治疗中的细胞免疫力.
主要方法:
- 合成和特征TMSN,EMSN和MSN与不同的骨结构.
- 评估了每个MSN类型的抗原载荷能力,细胞吸收,活性氧物种 (ROS) 生成和淋巴结向.
- 在临床前模型中评估了免疫激活和治疗效率.
主要成果:
- 这三种MSN都显示出增强瘤免疫疗法的细胞免疫力的潜力.
- 与EMSN和MSN相比,TMSN在抗原加载,细胞吸收,ROS生成,淋巴结向,免疫激活和治疗疗效方面表现优越.
- MSN的化学结构显著影响其免疫调节特性和治疗结果.
结论:
- 该研究阐明了不同MSN作为纳米辅助剂的结构功能关系.
- 由于其增强的特性,TMSN代表了高级瘤免疫疗法的非常有前途的候选人.
- 这些发现为设计和开发用于临床转化有效的中孔二氧化纳米辅助剂提供了新的框架.
更多相关视频
11:15A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.3K
08:02In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
2.6K
相关概念视频
Tumor Immunotherapy
554
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
554
Cancer Vaccines
399
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
399
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K
Mesenchymal Stem Cells
4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
