普雷尼松降低了成年人接受良性口腔喉手术的阿片类药物的使用
Joann M Butkus1, Emily S Sagalow1, Samuel Alfonsi1
1Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
概括
在接受口腔大手术的成年人中,术后使用普得尼松显著减少了1.62倍的阿片类药物依赖. 类固醇没有影响疼痛评分或并发症,这表明在多式联络性疼痛管理中发挥了作用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 在口腔喉手术后,阿片类药物依赖是一个重大问题.
- 有效的疼痛管理策略对于最大限度地减少阿片类药物使用和改善患者的治疗结果至关重要.
研究的目的:
- 评估术后普得尼松在良性口腔喉手术后减少阿片类药物消费的疗效和安全性.
- 评估普得尼松对疼痛评分,并发症率和阿片类药物补充率的影响.
主要方法:
- 一项前性队列研究在一个单一的三级医疗机构进行.
- 包括接受桃体切除术,桃体切除术和腺切除术,或uvulopalatopharyngoplasty的患者.
- 通过患者调查评估了阿片类药物的使用,疼痛评分和类固醇合规性.
主要成果:
- 与未接受类固醇治疗的患者 (n=29,467 MME;P < 0.001) 相比,接受普得尼松缓解剂 (n=43) 的患者消耗的阿片类药物显著减少 (285 MME).
- 在非类固醇队列中,阿片类药物的消费量是非类固醇队列的1.62倍 (P < 0.002).
- 两组之间没有观察到疼痛得分,并发症率或补充率的显著差异.
结论:
- 手术后使用普得尼松与阿片类药物消费减少1.62倍有关.
- 皮质类固醇并没有影响疼痛评分,并发症率或补充率.
- 普雷尼松可以被视为成人口腔大手术多模式疼痛管理策略的一部分,这需要进一步调查.
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