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依赖Lhs1的ERAD是由跨膜域上下文决定的

Maria Sukhoplyasova1, Abigail M Keith1, Emma M Perrault1

  • 1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, U.S.A.

The Biochemical journal
|September 13, 2023
PubMed
概括

细胞内膜网膜护航者Lhs1针对特定的非糖基化跨膜蛋白与两个跨膜域 (TMDs) 进行降解. Lhs1-依赖性降解还涉及Hrd1泛素酶,为基质识别提供了洞察力.

关键词:
细胞内膜网膜的内oplasmic网膜.分子的陪伴者是分子的陪伴者.蛋白质酶体是一种蛋白质酶体.跨膜蛋白质是一种跨膜蛋白质.

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