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维生素D3可以减轻自身免疫性炎症,这种炎症是由SLE中髓状树突细胞的激活引起的

Mingfang Li^1,2,3, Li Luo^1,2, Chuanchuan Lin²

¹Department of Dermatology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Experimental dermatology

|September 13, 2023

概括

维生素D (VitD3) 抑制了系统性红斑狼 (SLE) 中的DNA免疫复合体激活髓状树突细胞 (mDCs). 这表明维生素D可能是通过恢复免疫平衡来治疗SLE的潜在疗法.

科学领域:

免疫学免疫学免疫学
内分泌学在内分泌学.
类风湿病学类风湿病学

背景情况:

系统性红斑狼 (SLE) 涉及免疫系统的调节失调.
维生素D是一种已知的免疫调节剂,缺乏与SLE严重程度有关.
DNA-免疫复合体 (DNA-ICs) 参与了SLE的发病.

研究的目的:

为了研究1,25(OH) 2D3 (VitD3) 对SLE中DNA-ICs对髓状树突细胞 (mDC) 激活的影响.
探索VitD3对SLE免疫系统平衡的影响.

主要方法:

从SLE患者血清中净化DNA-ICs,并从健康捐赠者中分离mDCs.
在体外研究评估mDCs的DNA-IC内部化和VitD3对细胞信号通路 (RelB,IL-10,TNF-α) 的影响.
在使用mDCs和CD4+T细胞进行的RelB促进体和共同培养实验中分析基因组乙化,以评估免疫细胞平衡 (Treg/Th17).

主要成果:

VitD3抑制了DNA-IC诱导的mDC激活,包括对RelB,IL-10和TNF-α的影响.
DNA-ICs刺激了RelB促进剂乙化,这种效应被VitD3阻止,涉及3 (HDAC3) 基因素脱乙酶.
VitD3抑制了DNA-IC介导的T细胞增殖和调节的细胞因子,恢复了Treg/Th17平衡.

结论:

自主DNA-ICs激活mDCs,有助于SLE的发病.
VitD3通过对RelB基因的负转录调节来抑制DNA-IC刺激的mDC激活.
VitD3通过调节mDC激活和维持免疫平衡来显示SLE的治疗潜力.

关键词:

1,25 (((OH) 2D3 3D3 3D3 3D3 3D3 3D3 3D3 3D3 3D4 3D4 3D5 3D6 3D7 3D8 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 3D9 含有DNA的免疫复合体.在Treg/Th17免疫平衡中.自免疫性炎症是一种自免疫性炎症.骨髓状的树突细胞细胞.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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