我如何治疗由攻击性淋巴瘤引起的中枢神经系统二次干扰
Juan Pablo Alderuccio1, Lakshmi Nayak2, Kate Cwynarski3
1Division of Hematology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.
Blood
|September 13, 2023
概括
二次性中枢神经系统 (CNS) 淋巴瘤 (SCNSL) 是具有挑战性的,但通过透中枢神经系统的免疫化疗和干细胞移植,可以看到更好的结果. 新兴的CAR T细胞疗法也对SCNSL患者有希望.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 血液学 血液学 血液学
背景情况:
- 二次性中枢神经系统 (CNS) 淋巴瘤 (SCNSL) 是一种罕见而困难的瘤疾病.
- 扩散性大B细胞淋巴瘤 (DLBCL) 是最常见的类型,但其他淋巴瘤也会影响中枢神经系统.
研究的目的:
- 审查目前的证据和临床场景来管理SCNSL.
- 根据现有数据,为治疗途径提供建议.
主要方法:
- 对SCNSL治疗的回顾性和单臂研究的审查.
- 讨论临床情景和支持证据.
主要成果:
- 在MARIETTA研究中,通过一种特定的免疫化学疗法方案,然后对SCNSL的DLBCL进行干细胞移植,证明了改善的结果.
- 抗CD19仿真抗原受体T细胞疗法在SCNSL中显示出新兴的疗效和可接受的神经毒性.
结论:
- 目前的SCNSL治疗建议基于有限的数据,强调需要进一步研究.
- 像CAR T细胞这样的新疗法代表了管理SCNSL的范式转变.
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