在使用KOSMIC,Bhattacharya和霍夫曼方法的巴基斯坦儿童血清的间接参考间隔
Clinical laboratory
|September 13, 2023
概括
建立儿科血清参考间隔 (RIs) 是一个挑战. 间接方法,如KOSMIC,为确定儿童和青少年的这些RI提供了经济和实用的替代方案.
科学领域:
- 临床化学 临床化学
- 儿科实验室医学 儿科实验室医学
- 参考区间的确定 参考区间的确定
背景情况:
- 为儿科患者群体建立准确的血清参考间隔 (RIs) 存在道德和实际挑战.
- 确定RI的传统方法往往很难在儿童中实施.
- 间接方法为估计儿科血清RI提供了可行的解决方案.
研究的目的:
- 用间接方法估计巴基斯坦儿科和青少年人口的血清参考间隔 (RIs).
- 评估三种间接算法 (KOSMIC,Bhattacharya,Hoffman) 的疗效,以确定血清RI.
- 为在资源有限的环境中建立儿科RI提供实用和经济的方法.
主要方法:
- 实验室信息系统的利用数据挖掘用于血清的结果从2013-2021年.
- 分析了0-18岁儿童群体的数据,分为三个年龄组.
- 应用预先验证的间接算法:KOSMIC,Bhattacharya和霍夫曼.
主要成果:
- 从0-18岁儿童获得了40,914个非重复的血清测试.
- 科斯米克,Bhattacharya和霍夫曼方法的表现与来自CALIPER队列的直接RI相提并论.
- 科斯米克方法在严格的1mg/dL总允许误差下显示出优异的性能.
结论:
- 倡导使用间接方法来计算儿科患者血清RI.
- 间接方法为直接方法提供了经济,实用和可行的替代方案.
- 支持间接方法来帮助儿科护理的临床决策,特别是在资源较少的环境中.
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