用于早期检测和治疗心力衰竭的预测生物标志物
Vignesh Mariappan1, Rajesh Srinivasan1, Ravindran Pratheesh2
1Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607402, India.
Heart failure reviews
|September 13, 2023
概括
识别循环生物标志物对于早期发现和治疗心力衰竭 (HF) 至关重要,这是一个日益严重的公共卫生问题. 本综述探讨了omics平台和生物标志物,包括与内皮生物学相关的生物标志物,以改善HF预测和个性化治疗策略.
科学领域:
- 生物分子科学 生物分子科学
- 心血管研究研究心血管研究
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是一个不断增长的全球健康问题,心力衰竭 (HF) 预计是导致死亡的主要原因.
- 肝炎是一种复杂的综合症,原因和病理生理学各异,涉及炎症,亡,纤维化和神经幽默路径.
- 在HF进展期间释放的循环生物分子可以表明亚临床变化和疾病严重程度.
研究的目的:
- 为发现心力衰竭生物标志物提供omics平台的全面概述.
- 讨论早期HF检测的现有和新型生物标志物,强调内皮细胞生物学.
- 突出识别生物标志物对于早期预测和个性化高频管理的重要性.
主要方法:
- 审查当前的omics技术用于心力衰竭中的生物标志物发现.
- 对HF的既定和新兴生物标志物的文献分析.
- 专注于与内皮功能和心血管健康相关的生物标志物.
主要成果:
- 奥米克斯平台提供了强大的工具,用于识别新的心力衰竭生物标志物.
- 几种循环中的生物分子显示出早期HF检测和监测的潜力.
- 与内皮细胞生物学相关的标志物对理解HF病变发生和进展具有重要意义.
结论:
- 早期识别循环生物标志物对于预测和管理心力衰竭至关重要.
- 多生物标志物策略和奥米克方法可以为HF患者提供个性化治疗策略.
- 进一步研究新型生物标志物,特别是与内皮功能相关的生物标志物,对于推进HF护理至关重要.
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