COVID-19患者的心声学参数及其与ICU死亡率的关联:一个前性的多中心观察性研究
Amarja Ashok Havaldar1, Merugu Vinay Kumar2, Raman Kumar3
1Department of Critical Care Medicine, St John's Medical College Hospital, 1st floor, MICU, Bangalore, 560034, India. amarjahavaldar@rediffmail.com.
心声图显示,严重的左心室缩功能障碍与COVID-19患者的ICU死亡率较高有关. 下一篇: 下一个e
科学领域:
- 临界护理医学 临界护理医学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 心声谱对于管理重症患者至关重要,有助于诊断和治疗各种疾病.
- COVID-19可能导致心脏功能障碍,需要对受影响患者的心声学参数进行研究.
研究的目的:
- 在重症监护室 (ICU) 检查COVID-19肺炎患者的心声学参数.
- 确定心声回声检测结果与ICU死亡率,ICU停留时间和机械通风持续时间之间的关联.
主要方法:
- 一项前性,观察性,多中心研究招募了573名入住ICU的COVID-19肺炎患者.
- 在入院后24-48小时内进行了心声评估,包括左心和右心功能以及左心室透静功能.
- 主要结局是ICU死亡率;次要结局包括ICU停留时间和机械通风时间.
主要成果:
- 在8.7%的患者中观察到严重的左心室 (LV) 缩功能障碍,并与死亡率增加相关 (OR2.48,p=0.037).
- 较低的e' (扩张功能指标) 也与较高的死亡率相关 (OR 0.897,p=0.046).
- 表明LV填充压力的E/e'比率没有显著;Troponin I,E/A比率和右心室 (RV) 扩张在幸存者和非幸存者之间是相似的.
结论:
- 通过心声学检测发现的严重的LV缩功能障碍是COVID-19患者ICU死亡率的重要预测因素.
- 虽然E/e'不显著,但较低的e'值与死亡风险增加有关.
- 心声图为重症COVID-19患者提供了有价值的预后信息.
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