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基于结构的设计和合成用于用于心血管炎症疾病的接10PANX1类似物

Arthur Lamouroux1, Malaury Tournier2, Debora Iaculli1

  • 1Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.

Journal of medicinal chemistry
|September 13, 2023
PubMed
概括

新的Pannexin1 (Panx1) 通道的宏环皮多米米特剂显示了增强的抑制和稳定性. 这些化合物,包括SBL-PX1-42和SBL-PX1-44,为炎症性疾病提供了改善的治疗潜力.

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