选择的基因NR6A1,RSAD2-CMPK2和COL3A1通过不同的模式,有助于Meishan猪的体型变化
Chenxi Liu1, Liming Hou1, Qingbo Zhao1
1Institute of Swine Science (Key Laboratory of Pig Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs (Nanjing)), Nanjing Agricultural University, Nanjing 210095, China.
Journal of animal science
|September 13, 2023
概括
对Meishan猪的基因分析揭示了NR6A1,RSAD2-CMPK2和COL3A1基因的独特基因组区域和突变,这些基因导致中等 (MMS) 和小 (SMS) 体型变化.
科学领域:
- 动物遗传学动物遗传学
- 基因组学就是基因组学.
- 定量特征位置 (QTL) 分析分析.
背景情况:
- 梅山猪以高生育率而闻名,被分为中等 (MMS) 和小 (SMS) 体型.
- 了解这种体型变化的遗传基础对于品种改进至关重要.
研究的目的:
- 为了确定因果基因和负责Meishan猪体型变化的基因组区域.
- 阐明MMS和SMS Meishan猪之间的差异背后的遗传机制.
主要方法:
- 基因组范围的选择性扫描分析使用来自Meishan猪的重新测序数据.
- 多omics方法包括从大腿软骨和肝脏的转录组数据.
- 对候选因果基因及其突变 (例如NR6A1) 的分析.
主要成果:
- MMS和SMS猪的基因组显示分层化,差异基因组间隔丰富体型QTLs.
- 在MMS中,NR6A1中的误解突变被积极选择,增加了身体长度.
- RSAD2-CMPK2和COL3A1基因表现出差异性单元型,并且与杂交猪的身体长度有关.
- 三个枢纽基因 (NR6A1,RSAD2-CMPK2,COL3A1) 在SMS组织中高度表达,可能阻碍骨发育.
结论:
- 基因组选择信号和特定的基因突变 (NR6A1) 导致了Meishan猪的体型差异.
- 在SMS猪中,RSAD2-CMPK2和COL3A1的差异表达表明它们在骨发育的减少中起作用.
- 这些发现提供了对梅山猪体型变化的遗传结构的见解.
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