无手分析尿液检测技术验证用于药物协助犯罪调查
Marina Avram1,2, Carter A Bodinger1, Madeline A Clark1
1PinPoint Testing, LLC, Little Rock, Arkansas 72202, United States.
Chemical research in toxicology
|September 13, 2023
概括
法医实验室现在可以使用新的ToxBox套件进行快速,可靠的药物测试. 这种"无人驾驶"技术简化了工作流程,并满足了药物犯罪调查的新认证标准.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
背景情况:
- 法医实验室需要高效可靠的技术来加快药物测试的周转时间.
- 新的学术标准委员会要求需要简化毒品犯罪调查的工作流程.
研究的目的:
- 开发一个简化的工作流程尿液药物测试,满足新的认证标准.
- 为简化法医分析创建"准备就绪"的"免手"测试技术.
主要方法:
- 验证了一种新的ToxBox法医测试套件,用于一个单一的分析程序,涵盖多种药物类别 (阿片类药物,二,大麻素,抗抑郁药等). ) 的情况.
- 利用悬浮状态技术稳定NIST可追溯的标准和试剂以"准备就绪"的格式.
- 在使用经过验证的方法在环境温度或60°C下进行化后进行测试的测试套件.
主要成果:
- ToxBox套件展示了方法性能指标,包括准确性,精度,测量不确定性和分析剂稳定性,满足认证要求.
- 悬浮状态技术在样品矩阵和试剂的存在下稳定了参考标准和工艺控制.
- 经过验证的"免手"测试策略已成功应用于复杂的法医测试工作流程.
结论:
- ToxBox套件为法医药物测试提供了一种简化,无需手的方法,提高了效率和可靠性.
- 这项创新技术解决了对毒品犯罪的定量和确认测试的分析挑战.
- 该研究提出了一种新的策略,简化复杂的法医测试工作流程,以满足不断变化的行业标准.
相关概念视频
01:15High-Performance Liquid Chromatography: Types of Detectors
614
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
614
01:29Urine Studies I: Urinalysis
38
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
38