图像学专业人员在职业暴露于电离和非电离辐射的过程中出现了氧还原失调
Iman M Ahmad1, Lisa Bartenhagen1, Kimberly Michael1
1Department of Clinical, Diagnostic, & Therapeutic Sciences, College of Allied Health Professions, University of Nebraska Medical Center (UNMC), Omaha, NE, USA.
International journal of radiation biology
|September 13, 2023
概括
影像专业人员的职业辐射暴露,包括电离辐射 (IR) 和非电离辐射 (NIR),增加氧化应激并改变抗氧化剂水平. 这表明需要监测这些工人的氧化还原平衡.
科学领域:
- 生物医学科学 生物医学科学
- 职业健康 职业健康 职业健康 职业健康
- 辐射生物学 辐射生物学
背景情况:
- 在成像部门的医疗保健专业人员面临着对电离辐射 (IR) 和非电离辐射 (NIR) 的慢性暴露.
- 了解这种职业暴露对细胞健康的影响对于制定保护策略至关重要.
研究的目的:
- 研究职业IR和NIR暴露对医院成像专业人员氧化应激和抗氧化生物标志物的影响.
- 为了比较不同成像专业群体和非暴露对照之间的生物标志物水平.
主要方法:
- 血液样本被分析为超氧化物 (O2•−) 作为氧化应激标志物.
- 测量了抗氧化酶的活性,包括超氧化脱酶 (SOD) 和催化酶 (CAT),以及谷氨比率 (GSH/GSSG).
- 研究组包括58名IR暴露 (放射学,核医学,放射治疗) 和8名NIR暴露 (超声波) 的专业人员,以及60名对照组.
主要成果:
- 与对照组相比,暴露于辐射的成像专业人员显示O2•−,SOD和CAT的血液水平明显高 (p < .05).
- 在暴露组中观察到GSH/GSSG比率显著下降 (p < .05).
- 与IR组相比,NIR组表现出较高的生物标志物水平.
结论:
- 对IR和NIR的慢性职业暴露与氧化还原失调有关.
- 这种不平衡可能导致细胞损伤,影响脂质,蛋白质和DNA.
- 需要进一步的研究来评估暴露成像专业人员定期健康查的长期影响和必要性.
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