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根据在线自我报告推断的2,4-丁丁醇的次致命毒性
Ali Abdelati1, Michele M Burns2, Michael Chary2,3,4
1Weill Cornell Medicine-Qatar, Ar-rayan, Qatar.
在线报道显示,高剂量的2,4-丁烯醇 (DNP) 与疲劳和出汗等不良反应的增加有关. 这种减肥剂经常与安纳波利克类固醇一起讨论.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 数字健康数字健康
背景情况:
- 2,4-丁烯醇 (DNP) 是一种线粒体毒素,用于减肥剂.
- 与DNP相关的死亡人数增加表明使用率正在上升.
- 现有的DNP毒性数据仅限于极端病例,造成对非致命剂量的知识差距.
研究的目的:
- 调查在线用户讨论中报告的DNP的剂量和不良影响.
- 从公开可用的互联网帖子中分析DNP使用模式和相关症状.
主要方法:
- 分析了从2017-2019年到5个论坛和Reddit的1,630个公共互联网帖子.
- 利用自然语言处理提取DNP剂量,报告的效果和共同提及的物质.
- 医学毒理学家对效应的可信性进行了验证.
主要成果:
- 通常报告的DNP剂量在每天150-450毫克之间.
- 过度出汗和疲劳是最常见的不良反应.
- 每天超过150毫克的剂量与显著更高的温度调节,疲劳相关和神经症状率有关.
结论:
- 每日较高的DNP剂量 (>150毫克) 与疲劳增加,体温升高和麻醉有关.
- 在线讨论经常将DNP与安卓代谢类固醇和其他减肥剂一起提及.
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