白质道和执行功能:对因果关系和相关性证据的审查
Monica Ribeiro1,2, Yordanka Nikolova Yordanova3, Vincent Noblet4
1Service de neuro-oncologie, Hôpital La Pitié-Salpêtrière, Groupe Hospitalier Universitaire Pitié Salpêtrière-Charles Foix, Sorbonne Université, 75013 Paris, France.
Brain : a journal of neurology
|September 13, 2023
概括
特定的白质道,包括体和上纵,对于工作记忆和灵活性等执行功能至关重要. 这些发现突出了管道在认知网络中的作用和潜在的临床影响.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 神经解剖学是一个神经解剖学.
背景情况:
- 执行功能是复杂的认知过程,对于目标导向行为至关重要.
- 这些功能依赖于分布式大脑网络中的复杂相互作用,由白质道支.
- 在影响白质的神经疾病中,执行功能受损是常见的,但具体的通道贡献仍然不清楚.
研究的目的:
- 审查因果和相关证据,将白质管道完整性与执行功能联系起来.
- 在健康和受损的成年人中识别特定的白质路径,对各种执行功能至关重要.
- 探索执行功能的功能神经解剖学.
主要方法:
- 系统审查使用在清醒手术期间直接电刺激,病变症状映射 (基于voxel和通道的) 和扩散张力成像的研究.
- 从健康和神经障碍成年人群的证据分析.
- 原因和相关数据的整合.
主要成果:
- 体,特别是前段,与所有执行过程一致相关.
- 上部纵向囊强烈支持执行功能,特别是工作记忆,其第二个分支对灵活性至关重要.
- 有证据表明,右侧网络用于响应抑制,涉及诸如右前丘脑辐射之类的通道,以及带束在抑制任务中的作用.
结论:
- 特定的白质通道,包括体,上纵,以及潜在的前端插入通道,在支持执行功能方面发挥着至关重要的作用.
- 这些发现阐明了执行功能的神经解剖学基础,并对理解和治疗影响白质的神经疾病有意义.
- 这项研究强调了白质完整性对更高层次认知的重要性.
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