立即保护喷雾用于抗感染和加速治愈恩皮罗斯症
Wei Guan1,2,3, Caixin Gong2, Shuilin Wu1,2,3
1School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Yaguan Road 135, Tianjin, 300072, China.
Advanced materials (Deerfield Beach, Fla.)
|September 13, 2023
概括
一种新的即时保护喷雾 (IPS) 使用益生菌提取物和黄来创建一种非抗生素杀菌剂. 这种喷雾剂有效地对抗烧伤中的耐药细菌,减少炎症并促进愈合.
科学领域:
- 生物材料科学 生物材料科学
- 传染病研究 传染病研究
- 伤口愈合 治愈 伤口愈合
背景情况:
- 深度烧伤需要长时间的治疗,以防止感染,通常使用抗生素.
- 抗生素耐药性增加构成重大威胁,导致治疗失败和死亡率.
- 传统的治疗方法与慢性感染和多药耐药细菌的出现作斗争.
研究的目的:
- 开发一种新型的非抗生素杀菌剂,用于治疗深度烧伤.
- 创建一个即时保护喷雾 (IPS) 快速创伤屏障形成和感染控制.
- 评估IPS对抗多药耐药细菌的疗效及其对烧伤愈合的影响.
主要方法:
- 来自Lactobacillus casei的益生菌提取物,模仿菌体尾尖,与黄结合,制造出非抗生素杀菌剂.
- 这些药物被纳入了一个快速凝喷雾剂,具有横角布局,可立即应用.
- 在体外和体外研究中,在烧伤模型中使用多耐药黄金葡萄球菌 (MRSA) 进行了实验.
主要成果:
- 即时保护喷雾 (IPS) 在体外证明了MRSA的100.00%杀菌.
- 在体内,IPS在受感染的烧伤中实现了96.14%的MRSA灭菌.
- 在老鼠烧伤模型中,IPS显著降低了炎症并促进了组织愈合.
结论:
- 开发的非抗生素杀菌剂,通过即时保护喷雾提供,为深度烧伤治疗提供了对常规抗生素有希望的替代方案.
- IPS提供了快速的物理和抗感染屏障,有效控制多药耐药细菌感染.
- 这种创新方法有助于减少炎症并加速烧伤的愈合过程.
相关概念视频
Hand hygiene
3.3K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.3K
Prevention of Further Absorption of Poison
851
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
851
Surface Membrane Barriers
1.2K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.2K
Methods of Sterilization II: Chemical Methods
6.5K
In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...
6.5K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
5.0K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
5.0K


