血型对脑转移患者死亡率的影响
Yilong Zheng1, Zheting Zhang2, Jiashen Zhao1
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Clinical neurology and neurosurgery
|September 13, 2023
概括
经过大脑转移手术的血型AB患者面临更高的死亡风险. 这一发现表明,ABO血型可能对大脑转移的生存结果具有预后价值.
科学领域:
- 神经外科 神经外科
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- ABO血型与癌症死亡率有关.
- ABO血型与大脑转移中的死亡率之间的关联尚未被探索.
研究的目的:
- 为了研究ABO血型和脑转移手术切除的患者的死亡率之间的关联.
- 确定 ABO 血型是否是该患者群体生存的独立预测指标.
主要方法:
- 一项回顾性,单中心研究包括158名从2011年到2019年手术切除脑转移的患者.
- 考克斯的比例危险模型被用来评估ABO血型与整体死亡率之间的独立关联,并对混因素进行调整.
主要成果:
- 血型AB的患者的平均整体存活时间为11.2个月,而11.7 (O),13.5 (B) 和14.4 (A) 个月.
- 单变分析显示,血型AB与较高的死亡风险相关 (p=0.017).
- 多变量分析证实AB型血液独立预测了较高的整体死亡率 (HR:2.29,95%CI:1.11-4.72,p=0.025).
结论:
- 血液型AB独立地与大脑转移的手术切除后的整体死亡风险增加有关.
- ABO血型可以作为脑转移患者的潜在预后指标.
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