脑筋疲劳症患者表现出眼肌性类似现象的眼
Alon Abraham1, Tanya Gurevich2, Roy N Alcalay2
1Neuromuscular Diseases Unit, Department of Neurology, Neurology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel-Aviv, Israel.
Journal of the neurological sciences
|September 13, 2023
概括
这项研究描述了三名男性患者的罕见眼睛疾病,这些患者患有晚期发病的肌痛性骨髓灰质炎 (MG). 这种情况涉及难以打开眼睛,呈现为orbicularis oculi肌肉的肌性疾病.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 临床电生理学 临床电生理学
背景情况:
- 骨髓灰质炎 (MG) 是一种自身免疫性疾病,影响神经肌肉结节.
- 眼部表现在MG中很常见,但这种特定疾病很少见.
- 在男性中晚期发作的MG存在独特的临床挑战.
研究的目的:
- 在患有肌痛性骨髓灰质炎的患者中描述一种新的肌痛性骨髓灰质炎类眼睛疾病.
- 详细说明这种疾病的临床,血清学和电生理学特征.
- 提出一个名字,并讨论这种罕见的MG相关的眼睛发现的病理生理学.
主要方法:
- 三名被诊断为晚发,抗乙胆受体抗体阳性MG的男性患者的回顾性病例系列.
- 综合性临床检查,包括对闭眼困难的评估.
- 眼肌的电肌图 (EMG),冰包测试,以及对pyridostigmine的反应.
- 症状的血清学,成像和视频记录.
主要成果:
- 患者在强迫或反射闭眼后难以打开眼睛,用冰袋和重复闭眼后情况有所改善,但用皮多斯提格明治疗后情况恶化.
- 电磁共振显示了前和前眼圈 (orbicularis oculi) 的持续肌肉活动,但不是轨道部分.
- 这种情况被描述为一种类似于肌的疾病,与典型的MG症状不同.
结论:
- 一种罕见的,类似于肌的前和前 septal orbicularis oculi 的疾病,可能发生在患有 myasthenia gravis 的患者身上.
- 这种眼部表现需要提高临床意识和进一步调查.
- 了解这种疾病扩大了对MG不同临床表现的了解.
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