相关实验视频
Updated: Jul 16, 2025

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
23.5K
在COVID-19患者中,下丘脑-垂体轴功能和上腺功能缺陷
Emre Durcan1, Aysa Hacioglu2, Zuleyha Karaca2
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Neuroimmunomodulation
|September 13, 2023
概括
COVID-19可能会损害下丘脑-垂体-上腺 (HPA) 轴,可能导致上腺功能缺陷 (AI). 临床医生应该考虑在COVID-19患者中使用AI,使用皮质醇测试进行诊断.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- COVID-19 (由SARS-CoV-2引起) 在全球造成了数百万人的死亡.
- SARS-CoV-2 感染会影响多个器官系统,包括内分泌器官.
- 下垂体-垂体-上腺 (HPA) 轴的功能障碍是COVID-19患者的一个关键问题.
研究的目的:
- 审查在COVID-19患者中评估HPA轴的文献.
- 强调在COVID-19的背景下诊断上腺功能缺陷 (AI) 的重要性.
- 讨论SARS-CoV-2感染期间AI的挑战和诊断方法.
主要方法:
- 文献综述侧重于COVID-19中的HPA轴功能.
- 分析病原体机制,包括免疫,血管和直接病毒效应.
- 讨论诊断挑战,包括基本皮质醇水平和ACTH刺激测试.
主要成果:
- SARS-CoV-2 可能导致一次性或二次性上腺功能缺陷 (AIs).
- 人工智能的临床表现往往是非特异性的,并与COVID-19症状重叠.
- 在重症COVID-19患者中AI的诊断标准缺乏共识.
结论:
- 在所有患有COVID-19的患者中,必须考虑上腺功能不足 (AI).
- 重复的基底皮质醇测量和ACTH刺激测试对于诊断至关重要.
- 及时诊断和管理AI可以防止COVID-19患者的潜在致命结果.
更多相关视频
相关概念视频
Hypothalamic-Pituitary Axis
60.4K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.4K
Adrenal Gland Disorders
1.6K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K
Hormones of the Adrenal Glands
2.5K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.5K
Physiological Foundation of Stress
83
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
83
Anatomy of the Adrenal Glands
2.4K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.4K
Major Hormones and Their Functions
485
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
485

