在大鼠中表达防御性面部反应的脑干电路
Amalia Callado Pérez1, Maxime Demers2, Arash Fassihi3
1Cervo Research Center, Université Laval, Québec City, Québec G1J 2R3, Canada; Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.
Current biology : CB
|September 13, 2023
概括
研究人员在老鼠中发现了一种控制呼吸停止 (呼吸暂停) 和面部微笑的脑干电路,以应对有害的鼻子刺激,揭示了保护性反射的新途径.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
背景情况:
- 大脑干调节重要功能,包括呼吸和呼吸暂停等保护性反射.
- 呼吸暂停,呼吸暂停,防止吸入有害物质.
- 现有的理论表明,阴道/喉或三角管通道介导呼吸暂停.
研究的目的:
- 为了研究壁底子核在调解呼吸暂停中的作用.
- 为了阐明底层的神经回路鼻刺激诱导的呼吸暂停反射.
主要方法:
- 在麻醉老鼠的电生理学记录和病变.
- 监测暴露于氨气蒸汽的警觉大鼠的呼吸和口腔表情反应.
主要成果:
- 确定了一条从鼻腔化学传感器的途径,通过壁面亚核到Bötzinger前和面部运动核.
- 氨气蒸汽的输送诱导了呼吸暂停和特有的面 (振动的延伸,鼻子纹,眼睛).
- 呼吸暂停反射独立于嗅觉通路.
结论:
- 墙体亚核是大脑干电路的关键组成部分,控制鼻刺激诱导的呼吸暂停.
- 这个电路将呼吸反射与面部表情联系在一起,这表明它在感觉和疼痛反应中发挥了作用.
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