超声波弹性学,磁共振弹性学和有限元模型的比较,以量化非线性剪切模量
Gwenaël Pagé1, Marion Bied1, Philippe Garteiser2
1BioMaps, Laboratoire d'Imagerie Biomédicale Multimodale, Université Paris-Saclay, CEA, CNRS UMR 9011, Inserm UMR 1281, Service hospitalier Frédéric Joliot, F-91401 Orsay, France.
Physics in medicine and biology
|September 13, 2023
概括
这项研究通过超声波弹性学和磁共振弹性学验证了非线性剪切模量估计. 这些发现支持非线性弹性学作为医学诊断的潜在新生物标志物.
科学领域:
- 生物物理学的生物物理.
- 医疗成像医学成像
- 材料科学 材料科学 材料科学
背景情况:
- 声波弹性理论描述了材料在压力下变化的特性.
- 非线性剪模是理解软组织生物力学的一个关键参数.
- 超声波 (US) 弹性学和磁共振弹性学 (MRE) 是用于评估组织硬性的先进成像技术.
研究的目的:
- 用声弹性理论验证非线性剪切模量 (A) 的估计.
- 为了比较来自美国弹性学和MRE的实验结果与有限元法 (FEM) 模拟.
- 评估非线性弹性图的潜力,以开发新的医学诊断生物标志物.
主要方法:
- 实验是在受控的单轴应力下对一个均的 agar-gelatin 幻影进行的.
- 超音速剪切波弹性图是使用超快的美国设备实现的.
- 磁共振弹性图 (MRE) 使用渐变回声序来编码位移.
- 开发了一种有限元法 (FEM),以模拟压力软组织中的剪切波传播.
主要成果:
- 在零应力下,从美国弹性图 (12.3 ± 0.3 kPa) 和MRE (11.5 ± 0.7 kPa) 中获得了类似的剪切模块.
- 在FEM模拟中,非线性剪切模块为-58.1 ± 0.7 kPa.
- 实验估计显示出与FEM的良好一致:AUS = -58.9 ± 9.9 kPa和AMRE = -52.8 ± 6.5 kPa.
结论:
- 该研究证实了使用剪波弹性学量化非线性剪模的有效性.
- 这些发现证明了非线性弹性学作为医学诊断的新生物标志物的潜力.
- 这项研究为在临床应用中推进非线性弹性学技术铺平了道路.
更多相关视频
相关概念视频
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
136
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
136
01:20Elastic Strain Energy for Shearing Stresses
216
As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
216
01:15Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
289
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
289
01:20Shearing Strain
369
The shearing strain represents a cubic element's angular change when subjected to shearing stress. This type of stress can transform a cube into an oblique parallelepiped without influencing normal strains. The cubic element experiences a significant transformation when exposed solely to shearing stress. Its shape alters from a perfect cube into a rhomboid, clearly demonstrating the effect of shearing strain. The degree of this strain is considered positive if it reduces the angle between...
369
01:15Strain and Elastic Modulus
3.7K
The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
3.7K
01:20Elasticity in Concrete
114
Upon subjecting concrete to moderate or high uniaxial compressive or tensile stresses, the strain response is non-linear relative to the stress applied. As the stress is removed, the resulting stress-strain curve deviates from the original path traced during loading, creating a hysteresis loop, indicative of the concrete's non-linear and non-elastic properties. Typically, a material's modulus of elasticity, which is a measure of the material's stiffness, is inferred from the linear...
114