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Updated: Jul 16, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
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Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

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综合优化和CYP的空间改造,以控制产品配置文件

Jiazeng Yang1, Yuguang Liu2, Dacai Zhong2

  • 1Shenzhen Key Laboratory for the Intelligent Microbial Manufacturing of Medicines, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China; Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055, China.

Metabolic engineering
|September 13, 2023
PubMed
概括

这项研究优化了P450单氧化酶 (CYPs) 和减少酶 (CPRs) 来产生酸 (QA),这是药品的关键化合物. 工程网络实现了高产量,展示了复杂分子合成的强大框架.

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