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有了类似的结果,早期的肺癌应该是肺移植的禁忌吗?
Connor S Spies1, Timothy N Ochoa2, Arya Pontula3
1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
The Annals of thoracic surgery
|September 13, 2023
概括
肺移植 (LTx) 接受者偶尔发现早期非小细胞肺癌 (NSCLC) 的存活率与没有癌症的患者相似. 然而,在扩展的肺部中,先进的NSCLC与较差的结果有关.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 移植手术 移植手术
背景情况:
- 活跃的原发性肺癌是肺移植 (LTx) 的一个禁忌.
- 对于LTx接受者患有早期非小细胞肺癌 (NSCLC) 的结局,偶尔在扩张的肺部中发现的结局尚未确定.
- 这项研究调查了LTx患者偶发早期NSCLC的存活率.
研究的目的:
- 为了确定LTx接受者是否偶然发现I期NSCLC的存活率与没有癌症的存活率相似.
- 分析接受LTx.治疗的肺癌患者的生存数据.
主要方法:
- 从2007年5月到2021年9月,对LTx受益人的回顾性分析.
- 通过病理学家报告,通过扩张的肺部识别偶然的肺癌.
- 卡普兰-梅尔分析用于估计生存统计数据.
主要成果:
- 在接受LTx的患者中,1.5% (1586人中有23人) 患有偶发性肺癌.
- 在I期NSCLC (n=9) 中,1年和5年生存率分别为88.9%和51.9%.
- 患有I期非小细胞性癌症的LTx接受者的生存率与没有癌症的接受者没有显著差异 (P=.96).
结论:
- 具有偶然发现的病态I期NSCLC的LTx接受者表现出与没有癌症的人相似的生存率.
- 所有与癌症相关的死亡发生在偶然发现的晚期NSCLC患者中.
- 在LTx时发生的病态I期肺癌似乎不会对生存结果产生负面影响.
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