定义临床相关的近端结节形
Jeffrey Hills1, Michael P Kelly2
1Orthopedic Surgery, University of Texas, San Antonio, TX, USA.
International journal of spine surgery
|September 13, 2023
概括
靠近结节 (PJK) 是一个频谱,而不是一个二进制条件. 将PJK视为连续性的认知可以改善诊断,并为成人脊柱形手术提供个性化医疗方法.
科学领域:
- 脊柱外科手术 脊柱外科手术
- 整形外科的研究研究.
- 生物机械工程 生物机械工程
背景情况:
- 靠近结节 (PJK) 和失败是成年脊柱形重建后的常见并发症.
- 目前对PJK的定义依赖于专家意见或统计值,可能导致错误分类.
- 更好地理解PJK是与脊柱融合和对齐相关的表现的频谱.
研究的目的:
- 提出一种范式的转变,理解近接节 (PJK) 作为一种疾病的谱.
- 倡导使用概率模型来预测成人脊柱形中近端结合性衰竭 (PJF).
- 为了重新定义无症状PJK的定义.
主要方法:
- 审查现有的文献和PJK的临床定义.
- 分析二分化连续临床措施的局限性.
- 对PJK和PJF的基于频谱的方法的概念框架.
主要成果:
- 由于连续变量的二分化,目前PJK/失败/故障的定义是不充分的.
- 基于频谱的理解承认PJK是一个连续的表现.
- 对于成人脊柱形的个性化药物,需要概率模型.
结论:
- 临近结节形/失败/崩应该被视为一个频谱,而不是离散的类别.
- 术语"无症状近端结节"比定义任意的临床相关性值更合适.
- 精准医学方法需要概率模型来预测近接节失效.
更多相关视频
04:19Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
Published on: November 8, 2024
463
07:44Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis
Published on: March 23, 2019
17.8K
相关概念视频
General Case of Eccentric Axial Loading
207
Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
207
Vertebral Column: Regions and Curvature
3.7K
The vertebral column or spine is a flexible column that supports the head, neck, and body and allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
3.7K
Unsymmetric Bending - Angle of Neutral Axis
338
Unsymmetrical bending occurs when a structural member is subjected to bending moments in a plane that does not align with the member's principal axes. This scenario typically arises in beams and other structural components when loads are applied at non-ideal angles, introducing complexities in stress analysis.
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
338
General Structure of a Vertebra
2.9K
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous...
2.9K
Mitral Valve Prolapse I: Introduction
21
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
21
Overview of the Axial Skeleton
5.4K
The skeleton is subdivided into two major divisions—the axial skeleton and the appendicular skeleton. The axial skeleton forms the vertical, central axis of the body. It includes all of the bones of the head, neck, chest, and back. It protects the brain, spinal cord, heart, and lungs. It also serves as the attachment site for muscles that move the head, neck, and back and for muscles that act across the shoulder and hip joints to move their corresponding limbs.
The axial skeleton of the...
The axial skeleton of the...
5.4K
