腰围轨迹与发生的非酒精性脂肪性肝病之间的关联
Jun-Hyuk Lee1, Soyoung Jeon2, Hye Sun Lee2
1Department of Family Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, the Republic of Korea; Department of Medicine, Hanyang University Graduate School of Medicine, Seoul 04763, the Republic of Korea.
Obesity research & clinical practice
|September 13, 2023
概括
追踪腰围 (WC) 变化可以帮助识别患非酒精性脂肪肝疾病 (NAFLD) 风险较高的个体. 越来越多的WC趋势与更高的NAFLD发病率有关,无论腹部肥胖症如何.
科学领域:
- 代谢健康 代谢健康
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 腰围 (WC) 是非酒精性脂肪肝疾病 (NAFLD) 的已知危险因素.
- 随着时间的推移,WC的变化与NAFLD的发展之间的关联尚未得到充分理解.
- 需要进行纵向研究,以澄清 WC 动态与 NAFLD 发病率之间的关系.
研究的目的:
- 调查不同腰围 (WC) 轨迹与非酒精性脂肪肝疾病 (NAFLD) 发生率之间的关联.
- 分析16年间的WC变化与NAFLD发展的关系.
- 为了确定 WC 趋势的增加是否预测了更高的 NAFLD 风险.
主要方法:
- 利用了2666名没有NAFLD的参与者的数据,随访时间为16年.
- 采用基于群体的轨迹建模,在6年的暴露期内将参与者分为增加或减少的WC组.
- 应用了考克斯比例危险回归来计算发生NAFLD的危险比率 (HR).
主要成果:
- 在平均9.7年的随访期间,799名参与者患上了NAFLD.
- 增加的WC轨迹与NAFLD风险显著增加有关 (调整HR:1.28;95%CI:1.07-1.53).
- 这种关联在各种子组中持续存在,无论基线腹部肥胖状况如何.
结论:
- 腰围的增加趋势是高非酒精性脂肪肝 (NAFLD) 风险的独立预测因素.
- 监测WC变化可以帮助识别容易感染NAFLD的个体.
- 通过WC监测的早期检测可能会鼓励对NAFLD进行预防性生活方式修改.
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