在早产婴儿中与死性肠球炎相关的危险因素:一个病例对照研究
Nathalie Lamireau1, Eva Greiner1, Jean-Michel Hascoët2
1Division of Neonatology, Maternité Régionale Universitaire, CHRU, Nancy, France.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
|September 13, 2023
概括
早期发病的感染是早产婴儿死性肠球炎 (NEC) 的重要危险因素. 肠道养做法也可能导致NEC的发生和严重程度.
科学领域:
- 新生儿科学 新生儿科学
- 胃肠病学 胃肠病学
- 儿科手术 儿科手术
背景情况:
- 结核性肠球炎 (NEC) 是早产婴儿的关键性胃肠道紧急情况.
- 其复杂的病理生理学尚未完全理解,需要对相关风险因素进行研究.
- 早期发现和干预对于改善早产新生儿的结果至关重要.
研究的目的:
- 确定与早产新生儿中NEC相关的产前,产周和产后因素.
- 调查早期感染和养习惯在NEC发展和严重性中的作用.
主要方法:
- 在新生儿重症监护病房进行了一项病例对照研究.
- 患有NEC (病例) 的早产婴儿与基于妊娠年龄,出生日期和分娩方式的对照进行了匹配.
- 在NEC发作之前的风险因素被追溯分析.
主要成果:
- 早期发病的感染与NEC (15%对6.6%,p<0.04) 和败血症 (28.3%对16.4%,p<0.02) 有意义地相关.
- 晚期开始的养和最初的连续肠道养与更严重的NEC相关 (分别p<0.02和p=0.03).
结论:
- 肠道失生症被认为是NEC的潜在危险因素.
- 早期发病的感染被证实是NEC的重要危险因素.
- 肠道养策略可能会影响NEC的发生和严重程度.
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