状细胞贫血儿童的青春期模式:喀麦隆的一项病例对照研究
Ritha Mbono Betoko1, Suzanne Sap2, Anastasie Yanda Alima3
1Department of Pediatrics, Faculty of Medicine and Pharmaceutical Sciences, Cameroon.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
|September 13, 2023
概括
在患有状细胞贫血 (SCA) 的儿童中,青春期往往会延迟,影响性成熟. 疾病的严重程度,包括感染和贫血,与这种延迟的青春期有关,需要定期监测.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 血液学 血液学 血液学
- 生殖健康 生殖健康
背景情况:
- 状细胞贫血 (SCA) 可以对儿童的青春期发育产生负面影响.
- 了解这些影响对于管理SCA患者的整体健康和福祉至关重要.
研究的目的:
- 研究喀麦隆SCA儿童青春期的临床和荷尔蒙特征.
- 为了确定与这一群体中延迟青春期相关的因素.
主要方法:
- 一项涉及64名患有SCA和匹配健康对照的儿童 (8-18岁) 的病例控制研究.
- 评估身体参数 (身高,体重,BMI,身体组成,Tanner阶段) 和激素水平 (AMH,FSH,LH,性激素).
- 使用曼·惠特尼·威尔科克森测试和多变量分析进行统计分析,以确定SCA严重程度和延迟青春期之间的关联.
主要成果:
- 27.3%的女孩和10%的男孩患有SCA观察到延迟青春期;初潮延迟了2年.
- 在SCA患者中,瘦身量较低 (p=0.03) 和男孩的抗穆勒尔激素水平显著更高 (p=0.018).
- 严重的感染,急性胸部综合征和低血红蛋白水平与SCA患者的性成熟延迟相关.
结论:
- 患有SCA的儿童经历延迟的青春期,受疾病严重程度的影响.
- 在SCA儿童的随访护理期间,定期进行青春期监测至关重要.
更多相关视频
08:23Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
9.9K
05:23Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
19.5K
相关概念视频
01:49Multiple Allele Traits
34.3K
The Concept of Multiple Allelism
34.3K
01:27Signs of Puberty
409
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
409
01:09Changes in the Appendicular Skeleton with Age
2.1K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.1K
01:24Chronic Kidney Disease II: Clinical Manifestations
29
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
29
01:35Pedigree Analysis
84.4K
Overview
84.4K
01:20Overview of Hematopoiesis
4.1K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.1K