结束但还没有结束:COVID-19持续存在的表观遗传效应
Brandon T Tran1, Ruoqiong Cao2, Katherine Y King3
1Program in Cancer and Cell Biology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA.
Trends in immunology
|September 13, 2023
概括
长期COVID是一个影响COVID-19后许多成年人的疾病,其原因尚不清楚. 一项新的研究揭示了严重COVID-19患者骨髓状免疫细胞及其前体的持久变化.
科学领域:
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 长期COVID (COVID后的情况) 影响了SARS-CoV-2感染后很大一部分成年人.
- 驱动长期COVID症状的潜在生物机制尚未得到充分理解.
- 假设免疫系统失调在持续的症状中起作用.
研究的目的:
- 调查严重COVID-19后患者免疫细胞的长期分子和细胞变化.
- 为了确定潜在的表观遗传和转录性变化,有助于长期COVID病原体.
- 探索严重的COVID-19对髓状血统细胞及其祖先的影响.
主要方法:
- 分析免疫细胞中的表观遗传修饰 (例如,DNA甲基化).
- 转录分析 (RNA测序) 用于评估基因表达模式.
- 具有严重COVID-19病史的患者与健康对照组之间的比较分析.
- 专注于髓状细胞及其原始细胞群.
主要成果:
- 在COVID-19严重后的患者中观察到髓状免疫细胞表观遗传景观的显著和持久的变化.
- 在这些髓状细胞中发现了明显的转录特征,表明了长期的功能变化.
- 这些表观遗传和转录变化也存在于髓状细胞原始体中,这表明早期生命编程效应.
- 这些发现表明,在严重的SARS-CoV-2感染后,持续的免疫细胞功能障碍.
结论:
- 严重的COVID-19可以诱导髓状免疫细胞及其祖先的持久表观遗传和转录性重编程.
- 这些持久的细胞变化可能有助于长期COVID的病理生理学.
- 针对这些免疫细胞变化的进一步研究可能为长期COVID提供治疗策略.
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