前列腺癌内转移的结构重组的演变
Francesca Khani1,2, William F Hooper3, Xiaofei Wang2
1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
NPJ precision oncology
|September 13, 2023
概括
前列腺癌的大脑转移显示了多种结构变化和频繁的AR,TP53和PI3K路径改变. 这些对侵袭性内传播的基因组洞察力可能会指导未来的前列腺癌治疗方法.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 癌症转移 癌症转移
背景情况:
- 前列腺癌的内转移是罕见的,但具有攻击性,需要更深入的分子理解.
- 鉴别这些转移对于开发向疗法和改善患者治疗结果至关重要.
研究的目的:
- 执行前列腺癌内转移的第一个全基因组测序 (WGS).
- 为了比较内转移的分子景观与初级瘤和非大脑转移.
- 确定基因组驱动因素和进化模式,有助于前列腺癌中大脑转移.
主要方法:
- 全基因组测序 (WGS) 对10个内前列腺癌转移进行了测序.
- 还从6种前列腺原发性瘤和36种非大脑前列腺癌转移中获得了WGS数据.
- 评估了临床和分子特征,包括结构变化和基因突变.
主要成果:
- 前列腺癌的内转移在复杂的结构变化中表现出比原发性瘤更大的多样性.
- 常见的异常包括AR基因变异 (70%),TP53功能丧失 (80%),RB1 (20%),BRCA2 (20%) 和PI3K/AKT/PTEN通路激活 (80%).
- 在大脑转移中发现的基因组变异通常存在于同一患者的其他部位的瘤中.
结论:
- 内前列腺癌转移具有独特和积极的分子特征.
- 基因组因素和进化瓶在大脑转移的发展中发挥着作用.
- 这些发现可以为前列腺癌脑转移的新诊断和治疗策略的开发提供信息.
相关概念视频
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
02:30Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
01:35Cancer Cell Migration through Invadopodia
2.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.3K