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Updated: Jul 16, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

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在现实环境中对CDK4/6抑制剂的反应的决定因素

Agnieszka K Witkiewicz1,2, Emily Schultz3, Jianxin Wang3

  • 1Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA. agnieszka.witkiewicz@roswellpark.org.

NPJ precision oncology
|September 13, 2023
PubMed
概括

现实数据表明,瘤特征如SBR得分和PR表达影响了乳腺癌中CDK4/6抑制剂的有效性. 在治疗期间的基因表达变化也预测了无进展的生存.

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