在住院患者中查无症状的Clostridioides difficile携带:叙述性审查
Mayan Gilboa1,2, Nadav Baharav3, Eyal Melzer4,5
1Infection Prevention Unit, Sheba Medical Center, Ramat-Gan, Israel. mayangilboa@yahoo.com.
Infectious diseases and therapy
|September 13, 2023
概括
检查医院患者是否有无症状的C. difficile携带者可能会减少与医疗相关的感染. 这种策略,结合隔离和抗生素管理,显示出希望,但需要进一步的研究.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 医疗保健管理的管理
背景情况:
- 困难菌感染 (CDI) 是美国领先的与医疗相关的感染,导致严重的疾病,死亡和成本.
- 识别和管理无症状携带者对于预防CDI传播和爆发至关重要.
- 无症状的携带者可以散发C. difficile子,导致医院环境污染.
研究的目的:
- 审查现有的关于在医院中查和隔离无症状C. difficile载体的文献.
- 评估查策略在降低CDI率方面的有效性.
- 为了确定无症状C. difficile携带的风险因素和影响.
主要方法:
- 关于C. difficile携带者查和隔离的观察性研究的文献综述.
- 查策略实施前后报告的CDI率的分析.
- 识别与无症状C. difficile携带相关的风险因素.
主要成果:
- 在大约10-20%的住院患者中检测到无症状的C. difficile携带.
- 观察性研究表明,查和隔离策略可以减少CDI发病率.
- 携带的危险因素包括最近住院,使用抗生素,年龄较大和免疫抑制.
结论:
- 在入院时对无症状携带者进行查,加上隔离和抗生素管理,是减少CDI的潜在策略.
- 目前的证据主要来自观察性研究,该策略尚未得到广泛采用.
- 需要进一步的研究来验证查的有效性,特别是在不同的C. difficile菌株和医疗保健环境中.
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