微量营养素补充剂作为抗氧化剂在改善精子质量和减少DNA碎片化方面发挥作用
Nguyen Dac Nguyen1,2, Minh Tam Le3,4, Nhu Quynh Thi Tran1
1Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, 53000, Vietnam.
Basic and clinical andrology
|September 13, 2023
概括
联合抗氧化剂疗法显著改善了精子质量,并减少了不孕男性的DNA碎片化. 三个月每天补充微量营养素可以提高精子度,总数和活力.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 营养科学 营养科学
背景情况:
- 增加的活性氧物种会对精子生成和精子质量产生负面影响.
- 男性不孕症通常与高精子DNA碎片化指数 (DFI) 有关.
- 氧化应激对男性生殖健康起着至关重要的作用.
研究的目的:
- 研究联合抗氧化剂疗法在改善精子质量和减少不育男性DNA碎片化的有效性.
- 评估微量营养素补充对精液分析参数的影响.
- 评估抗氧化剂治疗后精子DNA碎片化指数 (DFI) 的变化.
主要方法:
- 一个三个月口服的微量营养素囊含有维生素E,叶酸,,L-氨酸,L-氨酸,辅酶Q10,L-氨酸和酸.
- 参与者包括具有高精子DNA碎片化指数的不育男性.
- 精液分析和精子染色质分散试验在基线和治疗后进行.
主要成果:
- 在抗氧化剂治疗三个月后,观察到精子质量的显著改善.
- 平均DNA碎片化指数 (DFI) 从45.6%降至34.8%.
- 精子度增加,精子总数显著增加,精子活力得到改善.
结论:
- 微量营养素补充剂有效改善不孕男性的精子质量和DNA完整性.
- 抗氧化剂治疗可以降低男性不孕不育和显著的精子DNA碎片化的DNA碎片化指数.
- 结合抗氧化剂治疗为提高男性生育能力提供了一个可行的策略.
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