身体脂肪分布与周围血液中的B淋巴细胞子集之间的关联
Pia Prechtl1,2, Timo Schmitz1, Nicole Pochert3,4
1Epidemiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Immunity & ageing : I & A
|September 13, 2023
概括
肥胖影响B淋巴细胞的组成,较高的体脂与较少的抗体分泌等离子弹和记忆细胞有关. 在肥胖个体中,内脏脂肪积累与天真CD19细胞增加有关.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
背景情况:
- 肥胖症的特点是慢性低度炎症和高水平的炎症性细胞因子.
- 脂肪组织与免疫系统的相互作用表明,脂肪积累可能会改变淋巴细胞群.
- 了解这些免疫变化对于代谢健康研究至关重要.
研究的目的:
- 为了研究身体脂肪分布和周围血液中的B淋巴细胞组成之间的关联.
- 为了确定内脏脂肪组织 (VAT) 和总体脂肪 (TBF) 是否影响B细胞子集频率.
主要方法:
- 用随机拦截模型在一年内检查了238名受试者.
- 通过基于光的流动细胞计量量化B淋巴细胞子集.
- 评估了增值税,TBF和B细胞子集频率之间的关联.
主要成果:
- 观察到体脂测量与血突变,记忆B细胞和IgM-IgD-细胞之间的不良关联.
- 内脏脂肪组织 (VAT) 与天真的CD19细胞有积极的关联,而总体脂肪 (TBF) 则没有.
- 增值税和TBF都显示出与IgD-only B细胞的积极关联.
结论:
- 身体脂肪积累与抗体分泌等离子弹和记忆B细胞的比例降低有关.
- 越来越多的内脏脂肪可能会导致更高比例的部分无能原始CD19细胞.
- 这些发现突显了身体脂肪对免疫细胞概况的影响.
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