住院COVID-19患者的维生素D状况与疾病严重程度和IL-5产生有关
Yali Qiu1,2, Wuping Bao3, Xue Tian3
1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Virology journal
|September 13, 2023
概括
低维生素D水平与严重的COVID-19结局有关. 这项研究发现,血清25-氧维生素D [25(OH) D]水平,结合IL-5和乙氨基酸计数,可以预测COVID-19死亡风险.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 关于维生素D与COVID-19严重程度之间的关联,存在相互矛盾的证据.
- 关联维生素D状态与COVID-19结果的潜在机制尚不清楚.
研究的目的:
- 研究血清25-基维生素D [25(OH) D]水平对住院患者COVID-19疾病严重程度的影响.
- 探索可能导致COVID-19感染期间25...OH) D水平发生变化的机制.
主要方法:
- 对399名住院COVID-19患者的回顾性分析.
- 测量血清25(OH) D度和细胞因子 (包括IL-5) 概况.
- 分析25(OH) D,细胞因子和疾病严重程度之间的相关性.
主要成果:
- 与较轻的病例相比,已故和危急的COVID-19患者观察到明显较低的25...OH) D水平.
- 血清25(OH) D和IL-5水平被确定为COVID-19严重程度的独立风险因素.
- 25 (((OH) D水平与IL-5表达有负相关,与CD8+T细胞计数有正相关.
结论:
- 血清25(OH) D状态,IL-5水平和乙酸细胞计数可以作为COVID-19死亡风险的预测因素.
- 在25~OH) D和IL-5之间存在负相关性,这表明需要进一步调查的潜在机械联系.
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