澳大利亚的耐火Helicobacter pylori感染:更新了多中心抗菌素耐药性
Jonathon P Schubert1,2, Paul R Ingram3,4, Morgyn S Warner1,5
1Faculty of Health Sciences, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Internal medicine journal
|September 14, 2023
概括
在澳大利亚,Helicobacter pylori抗生素耐药性的高率是越来越令人担忧的. 这项研究发现了对常见抗生素的显著耐药性,影响了治疗的有效性,需要更新的根除策略.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 杆菌感染导致全球显著的发病率和死亡率.
- 根除率下降与抗菌素耐药性增加有关.
- 澳大利亚有限的数据存在,以指导H. pylori根除治疗选择.
研究的目的:
- 评估当前澳大利亚H. pylori抗生素耐药性率.
- 为了评估先前根除疗法失败的患者的耐药性.
- 为当地根除实践提供信息.
主要方法:
- 来自两个病理学实验室 (2018-2022) 的H. pylori分离物的回顾性分析.
- 涉及的样本来自西澳大利亚 (WA) 和南澳大利亚 (SA).
- 计算了抗菌素耐药性率,并比较了各州之间的时间趋势.
主要成果:
- 克拉里思罗米辛的耐药性为82%,美特罗尼达68%,莱沃弗洛克萨22%和利芬皮辛14%.
- 在63%的患者中发现了多抗性分离物.
- 与WA相比,在SA中观察到较低的克拉里胺素耐药率和多重耐药率.
结论:
- 在澳大利亚的患者中,高水平的H. pylori抗菌药物耐药性,包括对levofloxacin的耐药性,已被证明.
- 目前的耐药性水平引发了人们对在经验性二线疗法中使用勒沃素的担忧.
- 加强对H. pylori耐药性的监测和意识对于指导澳大利亚根除实践至关重要.
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