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在胰腺移植接受者中的BK多重病毒DNAemia与胰腺-脏接受者相比

Zachary A Yetmar¹, Yogish C Kudva², Maria Teresa Seville³

¹Division of Public Health, Infectious Diseases, and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Clinical transplantation

|September 14, 2023

概括

在胰腺移植接受者中,BK多聚马病毒 (BKV) DNAemia 很常见,但不会损害功能. 然而,BKV DNAemia与胰腺异位移植失败有关,需要进一步研究.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
移植手术移植手术
病毒学病毒学

背景情况:

乙基多病毒 (BKV) 感染是移植后的常见并发症.
有限的数据存在于BKV流行病学和胰腺移植接受者的结果.

研究的目的:

研究胰腺移植受体中BKVDNAemia的发生率和结果.
为了比较不同类型的胰腺移植之间的BKVDNAemia率和相关并发症.

主要方法:

对466名成年胰腺移植受体 (2010-2020) 的回顾性队列研究.
主要结局:BKV DNAemia.主要结局:BKV DNAemia.主要结局:BKV DNAemia.主要结局: 二次结果:功能下降,末期病,胰腺异位移植失败.
使用考克斯回归分析来确定相关因素和结果.

主要成果:

与SPK接收者 (32.9%) 相比,PTA接收者BKVDNAemia发病率 (8.8%) 和持续时间较低.
BKVDNAemia与胰腺异位移植失败有关 (aHR 2.14) 但与PTA接受者的脏不良结果没有关联.
淋巴缺血,非PTA移植和年龄较大是BKVDNAemia的危险因素.

结论:

在胰腺移植接受者中,尤其是SPK中,BKVDNAemia很普遍,但在PTA接受者中,它似乎不会对原生功能产生负面影响.
BKV DNAemia 是胰腺全移植失败的重要危险因素.
需要进一步研究BKV脏病发病率和该人群的长期脏结果.

关键词:

这就是BK病毒.整体移植失败的原因是腎臟移植腎臟移植脏病是一种神经病.胰腺移植胰腺移植

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