慢性饮酒会影响男性的淋巴腺轴:从分析中得出的结果
Daniele Santi1,2,3, Angelo Cignarelli4, Matteo Baldi5
1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Andrology
|September 14, 2023
概括
慢性饮酒会显著降低健康男性的丸激素水平. 这次元分析发现总T,自由T和SHBG较低,雌激素增加,表明潜在的淋巴腺轴抑制.
科学领域:
- 内分泌学 在内分泌学.
- 男人的健康 男人的健康
- 生殖健康 生殖健康
背景情况:
- 低丸激素 (阴性恋) 影响2-13%的男性,并与心血管问题有关.
- 生活方式因素,包括酒精摄入量,可以影响荷尔蒙水平并导致内分泌系统疾病.
- 以前的研究表明,酒精会对精子生产和荷尔蒙平衡产生负面影响.
研究的目的:
- 进行全面的元分析,评估酒精消费对成人男性血清丸激素度的影响.
- 综合来自受控临床试验的发现,以确定酒精摄入量与水平之间的关系.
主要方法:
- 文献搜索侧重于对照性临床试验,将酒精消费者与非消费者或安慰剂组进行比较.
- 测量的主要结果是总丸激素血清度的差异.
- 埃格尔的测试被用来评估出版偏见.
主要成果:
- 对30项涉及10,199名男性的试验的分析显示,酒精消费显著降低了总 (MD = -4.02),自由T (MD = -0.17) 和SHBG (MD = -1.94).
- 酒精摄入与雌激素的增加有关 (MD = 7.65) 并对黄素化激素 (MD = -0.15) 有中性影响.
- 这些效应观察到的是长期饮酒的健康男性,而不是饮酒障碍者或急性饮酒后的健康男性.
结论:
- 在健康的男性中,慢性饮酒似乎抑制了淋巴腺轴.
- 精确的病理生理机制将酒精暴露与改变的类固醇生成联系起来,需要进一步调查.
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