骨髓微环境参与t-MN:专注于介质细胞干细胞
Giulia Falconi1, E Galossi1, H Hajrullaj1
1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Mediterranean journal of hematology and infectious diseases
|September 14, 2023
概括
与治疗相关的髓状瘤 (t-MN) 是由于细胞毒性治疗的并发症而产生的. 骨髓介质干细胞 (BM-MSCs) 功能障碍通过改变骨髓微环境并支持恶性血液形成,为t-MN作出贡献.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 干细胞生物学 干细胞生物学
背景情况:
- 与治疗相关的髓状瘤 (t-MN) 是细胞毒性疗法 (CT) 的晚期并发症.
- 从历史上看,t-MN仅归因于血液形成干细胞/原始细胞 (HSPC) 中的DNA损伤.
- 新出现的证据表明,骨髓微环境 (BMM),特别是骨髓介质干细胞 (BM-MSCs),与t-MN病原发生有关.
研究的目的:
- 审查BM-MSCs在与治疗相关的骨髓瘤 (t-MN) 病变发生过程中的作用.
- 探索CT如何影响BM-MSC功能,并有助于恶性血液形成.
- 总结从t-MN患者的BM-MSC中观察到的变化.
主要方法:
- 文献综述侧重于BM-MSCs在t-MN中的作用.
- 在细胞毒性治疗的背景下,研究BM-MSC功能的研究分析.
- 在t-MN患者和健康对照中,BM-MSC特征的比较.
主要成果:
- 化疗/放射治疗可以损害BM-MSCs,改变其功能并促进炎症和恶性血液形成.
- 来自t-MN患者的BM-MSCs表现出减少的增殖,改变的形态,增加的衰老,以及对HSCs的支持受损.
- 在t-MN相关的BM-MSC中观察到缺陷的骨质分化和免疫调节性质.
结论:
- BM-MSCs是t-MN病原体的关键参与者,它们的贡献超出了对HSPCs的直接DNA损伤.
- 功能障碍的BM-MSCs创造了一个亲恶性微环境,有利于t-MN的发展.
- 进一步研究t-MN-MSCs的遗传和功能概况对于预后和治疗方面的进展至关重要.
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