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Updated: Jul 16, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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在A3腺受体的试验依赖逆激动:当中性不是中性时

Eline Pottie1, R Rama Suresh2, Kenneth A Jacobson2

  • 1Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

ACS pharmacology & translational science
|September 14, 2023
PubMed
概括

这项研究使用NanoBiT试验探索了A3腺素受体 (A3AR) 的逆激动作用. 几种A3AR对抗剂在β-arrestin招募和cAMP测定中显示出逆激动作用,但在G蛋白测定中没有.

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